Recently, a study confirming the efficacy of improving brain function through the taking of Tongkat Ali. This study measured the change in neurons in rats brains and determined a significant increase in immunohistochemistry. i
The study aimed to explore the neuroanatomical functional site of Eurycoma longifolia (EL) extracts, commonly known as Tongkat Ali, in rat spinal nucleus using c-Fos immunohistochemistry. The results revealed a significant increase in the number of c-Fos immunoreactive neurons in both the dorsal and ventral nuclei of rats following intraperitoneal administration of Tongkat Ali at 8mg/kg. This finding suggests that Tongkat Ali exhibits neuromodulatory effects on sensory and motor neurons, indicating its potential impact on neurological functions. Remarkably, this study represents the first report indicating the involvement of EL in motor and sensory neuromodulation, underscoring the need for further research to elucidate the underlying molecular mechanisms driving Tongkat Ali-induced sensory and motor neuromodulation.
In conclusion, the study provides compelling evidence of Tongkat Ali's ability to modulate sensory and motor neurons in the rat brain nervous system. The observed increase in c-Fos expression suggests an enhanced neuronal activity in response to Tongkat Ali administration, pointing towards its potential therapeutic applications in neurological disorders. However, further investigations are warranted to delve deeper into the molecular mechanisms underlying Tongkat Ali's neuromodulatory effects, paving the way for the development of novel therapeutic strategies harnessing the neuroprotective properties of this natural extract. This study marks a significant advancement in understanding the neuropharmacological actions of Tongkat Ali and underscores its potential as a valuable therapeutic agent in neurological research and clinical practice.
i Kazi, Jamil Ahsan, and Norshimah Ali Yaakob. "Eurycoma longifolia Jack (Tongkat Ali) induced c-Fos expression in sensory and motor neurons of the rat brain nervous system." Advances in Environmental Biology, vol. 9, no. 17 S3, Aug. 2015, pp. 24+.